In a small clinical trial, customized mRNA vaccines against high-risk skin cancers appeared to reduce the risk of cancer recurrence and death by nearly 50 percent over five years when compared with standard treatment alone. That's according to Moderna and Merck, the two pharmaceutical companies that have collaborated on the experimental cancer vaccine, called intismeran autogene (mRNA-4157 or V940).

So far, the companies have only reported the top-line results in a press release this week. However, the results align closely with previous, more detailed analyses from the trial, which examined rates of recurrence and death at earlier time points, specifically at two years and three years after the treatment. More data from the trial—a Phase 2 trial—will soon be presented at a medical conference, the companies said. A Phase 3 trial is also underway, with enrollment complete.

The ongoing Phase 2 trial included 157 patients who were diagnosed with stage 3 or stage 4 melanoma and were at high risk of having it recur after surgical removal. A standard treatment to prevent recurrence after such surgery is immunotherapy, including Merck's Keytruda (pembrolizumab). This drug essentially enables immune cells, specifically T cells, to attack and kill cancer cells—something they normally do. But, in many types of cancers, including melanoma, cancer cells have the ability to bind to receptors on T cells (called PD-1 receptors), which basically shuts the T cells down. Keytruda works by physically blocking the PD-1 receptors, preventing cancer cells from binding and keeping the T cells activated so they can kill the cancer.

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Pharmaceutical executives are finally saying how they really feel about the extreme anti-vaccine agenda Health Secretary Robert F. Kennedy Jr. has been ruthlessly implementing—and it's not pretty.

According to reporting from Bloomberg at the J.P. Morgan Healthcare Conference that ended today in San Francisco, pharmaceutical executives who had previously been careful to avoid criticizing the Trump administration appear to have reached a breaking point, with Pfizer CEO Albert Bourla offering some of the most candid comments.

"I am very annoyed. I'm very disappointed. I'm seriously frustrated," Bourla said. "What is happening has zero scientific merit and is just serving an agenda which is political, and then antivax."

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For years, the Food and Drug Administration provided an informational webpage for parents warning them of the dangers of bogus autism treatments, some promoted by anti-vaccine activists and "wellness" companies. The page cited specifics scams and the "significant health risks" they pose.

But, under anti-vaccine Health Secretary Robert F. Kennedy Jr.—who has numerous ties to the wellness industry—that FDA information webpage is now gone. It was quietly deleted at the end of last year, the Department of Health and Human Services confirmed to Ars Technica.

The defunct webpage, titled "Be Aware of Potentially Dangerous Products and Therapies that Claim to Treat Autism," provided parents and other consumers with an overview of the problem. It began with a short description of autism and some evidence-based, FDA-approved medications that can help manage autism symptoms. Then, the regulatory agency provided a list of some false claims and unproven, potentially dangerous treatments it had been working to combat. "Some of these so-called therapies carry significant health risks," the FDA wrote.

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Under anti-vaccine Health Secretary Robert F. Kennedy Jr., federal health officials on Monday announced a sweeping and unprecedented overhaul of federal vaccine recommendations, abruptly paring down recommended immunizations for children from 17 to 11.

Officials claimed the rationale for the change was to align US vaccine recommendations more closely with those of other high-income countries, namely Denmark, a small, far less diverse country of around 6 million people (smaller than the population of New York City) that has universal health care. The officials also claim the change is necessary to address the decline in public trust in vaccinations, which has been driven by anti-vaccine activists, including Kennedy.

"This decision protects children, respects families, and rebuilds trust in public health," Kennedy said in a statement.

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